TETRAZOLE-1-ACETIC ACID

PRODUCT IDENTIFICATION
CAS NO. 21732-17-2

TETRAZOLE-1-ACETIC ACID

EINECS NO.  
FORMULA C3H4N4O2
MOL WT. 128.0902

H.S. CODE

  

TOXICITY

  
SYNONYMS TAA; Tetrazol-1-yl acetic acid;
1H-Tetrazole-1-Acetic Acid; Tetrazol-1-acetic acid;
SMILES

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystalline powder
MELTING POINT

125 - 129 C

BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION  

REFRACTIVE INDEX

 

NFPA RATINGS Health: 1; Flammability: 1; Reactivity: 0
FLASH POINT

125 C

STABILITY Stable under ordinary conditions.
GENERAL DESCRIPTION & APPLICATIONS
Tetrazole is one of a class of organic heterocyclic compounds containing a five-membered diunsaturated ring structure composed of four nitrogen atoms and one carbon atom. The simplest member of the tetrazole family is tetrazole itself, white to pale yellow crystalline solids with a weak characteristic odor; soluble in water and alcohol, melts at 156 C. Tetrazole is explosive. It is used as a gas generating agent for air bags. Shipment of tetrazole is available only as a solution in some countries. Tetrazole and its derivatives are used for biological activities such as antiviral, antibacterial, antifungal and antituberculous. They are used as catalysts in the synthesis of phosphonates.

Oligonucleotide is a short DNA (deoxyribonucleic acid) or RNA (ribonucleic acid) sequence, typically made up of a few (2–20) covalently linked nucleotides. In molecular genetics, a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe for detecting complementary DNA or RNA. Oligonucleotides are currently used for genomic,proteomic and drug discovery technologies. Tetrazole is the traditional oligonucleotide synthesis activato for good coupling efficiency and to decrease the coupling times. But there are disadvantages of tetrazole; crystallisation problem from solution and potential explosive property at room temperature. Some alternatives have been recommended;

  • 5-Ethylthio-1H-tetrazole [CAS RN: 89797-68-2]
  • 5-Methylthio-1H-tetrazole [CAS RN: 29515-99-9]
  • 5-Benzylthio-1H-tetrazole [CAS RN: 21871-47-6]
  • 5-Nitrophenyl-1H-tetrazole
  • 4,5-Dicyanoimidazole [CAS RN: 1122-28-7]

    • Tetrazole-1-Acetic Acid is used as an intermediate of Cephalosporin side chains.

    SALES SPECIFICATION

    APPEARANCE

    		 white crystalline powder

    ASSAY

    98.0% min

    LOSS ON DRYING

    0.5% max
    MELTING POINT

    125 - 129 C
    TRANSPORTATION
    PACKING

    20kgs in drum

    HAZARD CLASS 173
    UN NO. FS0001
    OTHER INFORMATION
    Hazard Symbols: C, Risk Phrases: 34, Safety Phrases: 26-36/37/38-45